Th2 cytokines (IL-13; IL-4R; CCL-13; CCL-17; CCL-18; CCL-26); Th22 cytokines (IL-22; S100As); Th17 (IL-17A; IL-23A; IL-12; PI3; DEFB4B and Th1 cytokines (IFNγ; CXCL9; CXCL10; CXCL11 were overexpressed in AD skin including IL-21. Here, PI3 is linked to Alzheimer disease.