IGHE and food allergy: South African children for example have similar IgE-mediated food allergy rates as described in industrialized countries (4) however it has been noted that African children display population specific IgE sensitization characterized by large positive food allergen skin prick test (SPT) wheals and high ImmunoCAP IgE levels with no clinically relevant food allergy (i.e., Allergen tolerance) and distinct atopic march trajectories have been observed in children of African ancestry (95–98).