The consequence of this genetic trait remains to be determined in other allergic diseases and food allergy in particular.<h4>Objectives</h4>Here, we describe three cases of peanut allergy among siblings from a single family of four: two of them were associated with HαT, and the third one was associated with the tryptase wild-type genotype.<h4>Methods</h4><i>TPSAB1/TPSB2</i> genotypes were determined by digital PCR. Here, TMPRSS11D is linked to peanut allergic reaction.