According to the enrichment criterion p < 0.01, sixteen KEGG pathways were selected, including Cell cycle, DNA replication, p53 signaling pathway, Oocyte meiosis, Cellular senescence, Gap junction, Fanconi anemia pathway, Mismatch repair, Homologous recombination, Progesterone-mediated oocyte maturation, Lysosome, Human T-cell leukemia virus 1 infection, Proteasome, Pathogenic Escherichia coli infection, and RNA transport (Table 2 and Fig. 2F). Here, TP53 is linked to escherichia coli infection.