Indeed, on one hand when the interferon-gamma signaling of T cells is impaired, such as in obesity [1], the feeding reduces the proresolutive migration of effector lymphocytes in response to infections and in presence of tumours [2], impairs the oral tolerance to antigens by T and B cells infiltrating the intestinal Peyer’s patches) [3] and it increases the risk of mortality in experimental models of pulmonary infection with P. Aeruginosa [4]. Here, IFNG is linked to obesity due to melanocortin 4 receptor deficiency.