Precocious puberty is classified as central precocious puberty (CPP; dependent on gonadotrophin-releasing hormone; GnRH), peripheral precocious puberty (PPP; independent of GnRH) and benign variants of PP like precocious adrenarche, precocious thelarche, precocious menarche (4, 5). The gene discussed is GNRH1; the disease is palmoplantar pustulosis.