Considering the entire cohort of 50 SSc patients, anti-centromere (ACA) was found in 25 cases (50.0%), while 20 patients were anti-Scl70 positive (40%); 5 patients (6.0%) were positive for other SSc-related antibodies (i.e., anti-RNA-III and anti-PM/Scl); and 2 patients (4.0%) showed only ANA positivity. The gene discussed is BTG3; the disease is systemic sclerosis.