The combination of exosomal dual‐lncRNAs with serum AFP and serum DCP not only effectively distinguished HCC from HC but also showed great potential for early HCC diagnosis, with statistically significant differences in the area under curve (AUC), thereby complementing the existing clinical markers [pairwise comparison of receiver operating characteristic curve (ROC) curves of each marker is shown in Table S4, Supporting Information]. This evidence concerns the gene ACE and hepatocellular carcinoma.