After identifying prognosis‐associated lncRNAs in HCC through transcriptome sequencing of exosomes enriched with a functionalized SiO2‐chip, we investigated the potential of using functionalized SiO2‐chip‐enriched exosomes for qRT‐PCR ‐based detection of LUCAT‐1 and EGFR‐AS‐1. The gene discussed is EGFR; the disease is hepatocellular carcinoma.