MAPT and supranuclear palsy, progressive, 1: Additionally, to investigate the Tau‐biotin PFF binding to Lag3 in a Tau conformation‐dependent manner, we extracted Tau seeds from brain samples of patients with neuropathologically confirmed progressive supranuclear palsy (PSP) and Pick's disease (PiD, which are subtypes under the fronto‐temporal lobar degeneration group of disorders).