In conclusion, we report RPS7 as a novel oncogenic RBP in HCC that contributes to HCC metastasis by posttranscriptionally regulating the expression of LOXL2 and activating LOXL2-mediated ITGB1/FAK/SRC signaling pathway (Fig. 8F). This evidence concerns the gene ITGB1 and hepatocellular carcinoma.