To investigate the importance of LOXL2 in metastasis process of HCC, two mutant plasmids, catalytic activity deletion mutant of LOXL2 (LOXL2-Δ) and catalytically inactive point mutant of LOXL2 (LOXL2-Y689F), were respectively constructed based on pcDNA3.1-3×Flag vector and stably transfected into Huh7 cells (Fig. S6A, S6B). The gene discussed is LOXL2; the disease is hepatocellular carcinoma.