CD4 and neoplasm: Based on canonical marker expression, seven major cell types were identified: B cells (286 normal cells, 0.36%; 33,027 tumor cells, 41.94%) and six immune cell types forming the tumor microenvironment (TME): CD4+ T cells (9,745 cells, 12.38%), CD8+ T cells (10,538 cells, 13.38%), NK cells (10,630 cells, 13.50%), CD14+ monocytes (12,565 cells, 15.96%), CD16+ monocytes (1,811 cells, 2.30%), and plasmacytoid dendritic cells (pDCs,138 cells, 0.17%) (Fig. 1C–E).