EZH2 and neoplasm: Conversely, whilst in the primary tumor of the Up responder there was significant enrichment of EZH2 binding at JBS promoters (3.5 × higher; chi-squared test P = 0), in the matched recurrence, there was significantly less EZH2 binding than expected (2 × less occupancy; chi-squared test P = 0; Fig. 6F).