Second, in terms of glomerular injury, WB revealed that dapagliflozin could increase the expression of podocin and nephrin as shown in Fig. 5B. In addition, in Fig. 5C, morphological staining revealed that in the DN group, the glomerulus manifests significant hypertrophy, mesangial hyperplasia, a loss of normal shape, and fibrosis. This evidence concerns the gene NPHS1 and liver dysplastic nodule.