To investigate and validate the significance of the PPI network-deduced YN proteins in BP regulation and connect the protein interactome to BP functional information, we selected four of the significantly BP-enriched KEGG-defined pathways, i.e., adrenergic signaling in cardiomyocytes (Fig. 10), HIF-1 signaling (Fig. 11), cGMP-PKG signaling (Additional file 1: Fig. S5) and DCM (Additional file 1: Fig. S6), which have been directly associated with hypertension and/or heart pathophysiology, e.g., [53–59]. The gene discussed is HIF1A; the disease is hypertensive disorder.