cGMP is formed in response to NO and natriuretic peptides, including the atrial natriuretic factor ANF (NPPA) (BN) and the brain natriuretic factor ANFB (NPPB) (BN), and has been shown to modulate hypertension via different mechanisms, as vasorelaxation or renin reduction [54]. This evidence concerns the gene NPPB and Hypertension.