cGMP is formed in response to NO and natriuretic peptides, including the atrial natriuretic factor ANF (NPPA) (BN) and the brain natriuretic factor ANFB (NPPB) (BN), and has been shown to modulate hypertension via different mechanisms, as vasorelaxation or renin reduction [54]. The gene discussed is REN; the disease is hypertensive disorder.