Finally, Meta-regression indicated no significant associations between 1-year overall survival and age (P = 0.25), total bilirubin level (P = 0.49), alpha-fetoprotein level (P = 0.2), tumor size within the range of 1.6 to 3.5 cm (P = 0.86) (Supplementary file Fig. S10). This evidence concerns the gene AFP and neoplasm.