CDKN1A and neoplasm: Furthermore, a study by Ryu et al. unveiled the relationship between PRMT1 and CDKN1A (P21), whereby co-transfecting cells with siPRMT1 and siCDKN1A resulted in spheroid formation and restored cell growth, suggesting the involvement of CDKN1A downstream of PRMT1 in regulating tumor growth and formation in HCC [68].