ECE2 and neoplasm: Another study demonstrated that ECE2, a prognostic biomarker of lung adenocarcinoma (LUAD), was found to have negative correlation with m6A modification-associated genes (HNRNPC, IGF2BP1, IGF2BP3 and RBM1), which suggested that ECE2 may affect the tumor progression of LUAD by influencing the methylation level of m6A [23].