SOX4 and familial pancreatic carcinoma: Chen et al. [30] illustrated that METTL14 down-regulation was associated with poor prognosis in patients with colorectal cancer (CRC); as well as METTL14 knockdown could significantly enhance the proliferation and invasion ability of CRC cells in vitro, and promote tumorigenicity and metastasis in vivo through regulating the expression and m6A level of SOX4. Another study of Wang et al. [31] reported that m6A levels were elevated in about 70% of pancreatic cancer samples, and METTL14 was the main enzyme that regulated m6A methylation.