METTL14 and cancer: METTL14, a member of “writers” in m6A modification, can enhance the activity of methyltransferase by recognizing RNA and methyl localization, and its mutation can reduce the catalytic activity and substrate specificity of methyltransferase, resulting in reversal of methylation efficiency of consensus GGACU and non-consensus GGAUU sequences, leading to the changes in m6A levels, thus contributing to cancer occurrence and tumor metastasis [26, 27].