After adjustment, tumor PLK4 IHC score > 3 (vs. ≤ 3) (HR: 3.918, P = 0.026), hypertension (HR: 3.108, P = 0.047), endometrioid carcinoma G3 (vs. endometrioid carcinoma G1/G2) (HR: 19.661, P < 0.001), clear cell endometrial carcinoma (vs. endometrioid carcinoma G1/G2) (HR: 30.569, P < 0.001), and high FIGO stage (HR: 2.413, P = 0.001) were independently associated with shortened OS (Table 4). The gene discussed is PLK4; the disease is neoplasm.