After adjustment, tumor PLK4 IHC score > 6 (vs. ≤ 6) (hazard ratio (HR): 3.156, P = 0.008), endometrioid carcinoma G3 (vs. endometrioid carcinoma G1/G2) (HR: 7.617, P = 0.002), serous endometrial carcinoma (vs. endometrioid carcinoma G1/G2) (HR: 5.393, P = 0.002), clear cell endometrial carcinoma (vs. endometrioid carcinoma G1/G2) (HR: 6.339, P = 0.003), and high FIGO stage (HR: 1.983, P < 0.001) were independently associated with shortened DFS (Table 3). The gene discussed is PLK4; the disease is endometrioid adenocarcinoma.