In EC patients who underwent surgical resection, tumor PLK4 IHC score > 3 (vs. ≤ 3) (P = 0.018), tumor PLK4 IHC score > 6 (vs. ≤ 6) (P = 0.010), age ≥ 60 years (vs. < 60 years) (P = 0.019), endometrioid carcinoma G3 (vs. endometrioid carcinoma G1/G2) (P = 0.001), clear cell endometrial carcinoma (vs. endometrioid carcinoma G1/G2) (P < 0.001), stromal cervical invasion (vs. none or epithelia) (P = 0.014), lymphovascular invasion (P = 0.024), and high FIGO stage (P = 0.005) were linked with worse OS. The gene discussed is PLK4; the disease is endometrioid adenocarcinoma.