XDH and chronic rhinosinusitis: For instance, SNP rs608574 linked with IL18 and showing association only females, regulates genes such as SRD5A2, CAPN13, SLC30A6, NLRC4, XDH and SPAST, and it is as well associated to traits and diseases (e.g., height, age started oral contraceptive pill, single delivery by caesarean section, treatment with diltiazem, chronic sinusitis, birth control pills and fistulae involving female genital tract).