While nontargeted microbubbles produced lower imaging signals in normal mammary tissues and malignancies that block B7-H3, Strong imaging signals were obtained in tumors expressing hB7-H3 by microbubbles conjugated to the B7-H3-targeted affibody (MBABY-B7-H3) [205], proving the B7-H3’s diagnostic utility in BC imaging. Here, CD276 is linked to breast cancer.