Variables associated with statistically significant differences in PFS or OS in univariate analyses (patient age, ECOG performance status, extent of resection, tumor multifocality, TERT mutation, EGFR expression, and the presence of perioperative complications) as well as several putatively clinically significant variables (WHO grade and treatment according to Stupp) were included in a multivariate survival analysis. The gene discussed is EGFR; the disease is neoplasm.