Through analysis of PRGs between normal and NASH samples, we found that most of differentially expressed PRGs were caspase family members (CASP6, CASP9, CASP3, CASP4) and inflammasome sensors (NLRP7, NLRP9, NLRP2, NLRP1, NLRP6). The gene discussed is NLRP1; the disease is metabolic dysfunction-associated steatohepatitis.