Through analysis of PRGs between normal and NASH samples, we found that most of differentially expressed PRGs were caspase family members (CASP6, CASP9, CASP3, CASP4) and inflammasome sensors (NLRP7, NLRP9, NLRP2, NLRP1, NLRP6). Here, NLRP6 is linked to metabolic dysfunction-associated steatohepatitis.