SIRPA blockade also rescued the numbers of CD8+ T cells and NKP46+ NK cells in tumour-bearing livers of Clec4fcreId3f/f mice (Fig. 5g and Extended Data Fig. 7e), the formation of the peritumoural CD8+ T cell and NKP46+ NK-rich zone (Fig. 5h and Extended Data Fig. 7f) and the production of IFNγ and TNF by CD8+ T cells and NK cells (Fig. 5i,j). Here, CD8A is linked to neoplasm.