Similarly, immunofluorescence staining in tumoural liver 2 weeks after intraportal injection of KPC cells in wild-type mice indicated that CCL3, CCL4 and CCL5, and IL-12, IL-15 and IL-18 are most prominently produced by KCs present at the tumour margin (Fig. 2h and Extended Data Fig. 5b). This evidence concerns the gene CCL3 and neoplasm.