Furthermore, genetic labelling of bone-marrow-derived cells from tumour-free and tumour-bearing mice using three genetic models (Cx3cr1gfp mice, Cxcr4gfp mice and Cxcr4creERT2R26LSL-tdT mice pulsed with 4-hydroxytamoxifen at 6 weeks of age), confirmed that most TIM4+ cells (KCs) from both CD206+ and CD206bright subsets are not labelled (Extended Data Fig. 2k–o). Here, MRC1 is linked to neoplasm.