Furthermore, we show that ectopic expression of ID3 in mouse bone-marrow-derived macrophages (BMDMs) and human hiPS cell-derived macrophages (hiPSC-Macs) is sufficient to endow them with the ability to orchestrate this vigorous phagocytic and lymphoid anti-tumoural activity in a variety of tumour models in vitro and in vivo. The gene discussed is ID3; the disease is neoplasm.