Immunofluorescence staining confirmed that the expression of chemokines CCL3, CCL4 and CCL5 and the cytokines IL-12, IL-15 and IL-18 by KCs in the liver of Clec4fcreId3f/f mice was reduced or abolished at the tumour margin and in the tumour in comparison to in the littermate controls (Fig. 4h and Extended Data Fig. 6c,d). The gene discussed is IL18; the disease is neoplasm.