SIRPA and neoplasm: In both cases, KCs represented the majority of macrophages in normal liver, but a minor subset in tumoural liver (Extended Data Fig. 9f,g), and expressed higher ID3, lower SIRPA and higher chemokine (CCL4, CCL3) and cytokines genes (IL18) in comparison to CD14+TIM4− tumour-associated macrophages (Extended Data Fig. 9h).