CCL2 and neoplasm: This profile included the increased expression of several receptors that are involved in macrophage activation and phagocytosis such as the activating receptors dectins that recognize carbohydrate antigens on tumour cells37, and C–C chemokines CCL2, CCL3, CCL4, CCL5, CCL6 and CCL7, and interleukins IL-12, IL-15 and IL-18, which are involved in the recruitment and activation of effector lymphoid cells at tumour sites38–42 (Fig. 2c and Extended Data Fig. 3b,c).