TNF and neoplasm: Finally, in a melanoma model in which B16F10 cells are injected subcutaneously in the two flanks of a wild-type mice, intratumoural injection of ID3-expressing BMDMs, but not control BMDMs, blocked tumour growth in the corresponding flank, but not the contralateral flank (Fig. 6h), and triggered accumulation of activated CD8+ T cells and NK cells producing IFNγ and TNF to the B16F10 tumours in the corresponding flank (Fig. 6h and Extended Data Fig. 10c,d).