CALCA and neoplasm: KC activation results in phagocytosis of live tumour cells, recruitment of NK cell and CD8+ T cells to the tumour and peritumoural niche through the production of chemokines, and activation of these lymphoid effector cells to proliferate and produce IFNγ and TNF, at least in part through the production of the cytokines IL-12, IL-15 and IL-18 (Extended Data Fig. 10e).