Finally, supernatants from cocultures of lenti-ID3 hiPSC-Macs and tumour cells were sufficient to trigger the proliferation of CD8+ T cells (Fig. 6d), the production of IFNγ by CD8+ T cells and NK cells (Fig. 6e), and the production of TNF by CD8+ T cells (Extended Data Fig. 10b), whereas the supernatant of lenti-control iPSC-Mac/tumour cell cocultures had little or no effect (Fig. 6d,e and Extended Data Fig. 10b). This evidence concerns the gene IFNG and neoplasm.