In addition, pro-inflammatory cytokines (IL-1RA, IL-1a), chemokines associated with trafficking of immune cells (CCL19/MIP-3b, FLT3-Ligand) and endothelial inflammation and -repair (CXCL1, EGF, RANTES, PDGF-AA) were elevated in PC participants. Here, IL6R is linked to pachyonychia congenita.