DSG2 and Moyamoya disease: DSG2 may interact with MMP-9 in Moyamoya disease vascular endothelial cells, causing impaired skeleton regulation in vascular endothelial cells in Moyamoya disease, which in turn leads to pathological vascular remodeling in Moyamoya disease and the interaction between the two may serve as a target for future treatment, which in turn inhibits the further development of Moyamoya disease.