In the high-risk subgroup, patients were significantly associated with the clinicopathological parameters of advanced T (p = 0.022), M (p = 0.010), and N stage (p = 0.006), advanced grading (p = 0.006), advanced AJCC stage (p < 0.001), higher ki-67 expression (p < 0.001), lower ER (p = 0.017), PR expression (p = 0.025), cancer emboli (p < 0.001), and perineural invasion (p < 0.001). This evidence concerns the gene ESR1 and cancer.