However, cuproptosis-related genes, including FDX1, LIPT1, LIAS, DLD, DLAT, and PDHB, failed to reach statistical differences by Kaplan–Meier analysis in our study and were unable to build a prognostic survival model, indicating the need for a more nuanced understanding of the roles of these genes in breast cancer. Here, LIAS is linked to breast carcinoma.