Our investigation into the relationship between CRHBP expression and drug response also revealed a positive correlation between CRHBP expression level and tumor responses to 12 chemotherapy drugs, including isotretinoin, Nelfinavir, and imiquimod (p < 0.05), and a negative correlation between CRHBP expression level and tumor responses to irofulven (p = 0.039). This evidence concerns the gene CRHBP and neoplasm.