We also explored into the connection between CRHBP and four different types of DNA methylation, and the findings revealed that in many malignancies, including PAAD, LUAD, LGG, etc., CRHBP was strongly connected with four different types of DNA methyltransferases (DNMT1, DNMT2, DNMT3A, and DNMT3B) (Fig. 8D). The gene discussed is DNMT3B; the disease is pancreatic adenocarcinoma.