CD4 and neoplasm: We compared the expression of CRHBP with the level of immune infiltration in each type of tumor, and TIMER results revealed a positive correlation between CRHBP and the number of all six immune cells, including B cells, CD4 + T cells, CD8 + T cells, neutrophils, macrophages, and dendritic cells in BRCA, CESC, and COAD, which were the top three tumor groups (Fig. 5A).