In model 3 (adjusted covariates of age, gender, OASIS, CCI, SOFA score, ethnicity, weight, MBP, respiratory rate, HR, SpO2, temperature, WBC, hemoglobin, platelet, potassium, chloride, anion gap, creatinine, BUN, ALT, AST, MI, CLD, CHF, renal disease, liver disease, severe liver disease, malignant cancer, RRT use, and vasopressor use, ventilator use), the effect size increase by 4% (HR: 1.04, 95% CI 1.03–1.04) for every 1 unit increase in APAR. The gene discussed is GPT; the disease is kidney disorder.