These findings are in line with previous genomic studies reporting that FGFR, BAP1 and IDH1/2 alterations cluster in a subgroup of iCCA patients that is distinct from the subgroup of iCCA patients with TP53, KRAS, SMAD4 and ARID1A alterations8,15. This evidence concerns the gene TP53 and infantile convulsions and choreoathetosis.