FGFR2 and infantile convulsions and choreoathetosis: In iCCA, most of detected FGFR genomic alterations (GAs) are FGFR2 activating fusions/rearrangements (up to 15% of cases); activating FGFR2 amplifications and mutations also occurs in this disease, even though with a lower frequency than fusions/rearrangements15–18.