FGFR2 and neoplasm: The levels of FGFR2 protein expression and signalling activation were then assessed in the subgroup of iCCA patients with wild-type FGFR2. Among these patients, 8 out of 29 cases (27.6%) showed a high FGFR2 expression, 13 cases (44.8%) a moderate expression, 6 cases (20.7%) a weak positivity and 2 cases (6.9%) did not express FGFR2 protein in the tumor tissue (Supplementary Fig. 6a–d).