STAT3 and cancer: The molecular interaction network analysis of Napabucasin overlaid with DEGs in high vs low MUC1 showed predicted inhibition of all stemness markers that are upregulated in cancers (orange line with inhibition), namely STAT3, MUC1, ALDH1A1, Notch1, Yamanaka factors MYC, SOX2, KLF4 and more, and predicted activation of FAS, p38 MAPK, JNK, Caspase 3 and BAX that are usually downregulated (blue lines with arrowhead), out of which only SOX2 was significantly differentially expressed (Fig. 5E).