STAT3 and cancer: Since MUC1 and STAT3 were found to regulate each other’s expression in an auto-inductive loop, we hypothesized that in high-MUC1 cancer cells, the STAT3-MUC1 pathway is constitutively activated as a survival pathway and therefore, high-MUC1 cells will be more sensitive to the anti-proliferative effect of STAT3-inhibitor Napabucasin.