Analysis of a large-cohort TCGA skin cutaneous melanoma dataset revealed variable expression of AR at the mRNA level in ~88% of all patients, and interestingly, the mRNA expression levels of AR appear to modestly increase from primary to metastatic specimens in male (p = 0.02) and female (not statistically significant, likely due to lower specimen numbers) patients (TCGA_SKCM; n = 473 melanoma cases; Fig. 1a, b). This evidence concerns the gene AR and melanoma.