AR and melanoma: In striking support of the notion that FUT4 signaling mediates the pro-invasive but not pro-proliferative effects of androgen/AR in melanoma, whereas treatment of matrigel plug-implanted melanoma spheroids with ARi abrogated both 3D spheroid growth and peripheral invasiveness into the matrigel, the ectopic expression of FUT4 only significantly rescued invasive but not the proliferative capacity of melanoma spheroid under ARi treatment (Fig. 4h).