Intriguingly, although WM793 cells were initially derived from a primary melanoma and were not previously reported to exhibit significant spontaneous metastatic ability in nude mice46,47, we observed induction of what appeared to be intravascularly trapped “micrometastatic” WM793 colonies in the lungs of mice bearing ectopic FUT4-expressing tumors, which were partially reduced by enzalutamide (FUT4-OE-CTL diet: ~13–14 intravascular colonies/lung; FUT4-OE-Enzal diet: ~6-7 intravascular colonies/lung; Fig. 7c and Supplementary Fig. 7a, b). The gene discussed is FUT4; the disease is melanoma.