Melanoma patient dataset analyses support the in vitro findings that AR-FUT4 axis augments the ability of melanoma cells to degrade extracellular matrix (ECM): FUT4 expression positively correlates with the level of matrix metalloproteinase 2 (MMP2) and MMP9, gelatinases that are known to degrade ECM and promote tumor metastasis40 (Supplementary Fig. 4i). Here, MMP9 is linked to melanoma.