Acute stimulation of AR+ melanoma cells with 100 nM dihydrotestosterone (DHT) triggered ~200% upregulation of total AR protein, with concomitant and marked nuclear translocation of AR, indicating that melanoma-expressed AR is responsive to androgen stimulation (WM793 cells in Fig. 1d, e; WM1366, IPC298, and A375 cells in Supplementary Fig. 1b, c). The gene discussed is AR; the disease is melanoma.