However, specific contributions of androgen-ZIP9 signaling across different cancers remain unclear: in breast and prostate cancer cells, androgen activates inhibitory G protein (Gi) through ZIP9 and induces apoptosis84,85, whereas in melanoma, androgen-ZIP9 signaling through YAP1 was reported to induce proliferation86. This evidence concerns the gene SLC39A9 and prostate carcinoma.