TNF and metabolic dysfunction-associated steatotic liver disease: Second, given that low-grade systematic inflammation plays a pivotal role in the pathogenesis of NAFLD, previous studies reported that remnant-C was positively linked to low-grade systematic inflammation indicated by C-reactive protein and tumor necrosis factor α, we speculated that low-grade systematic inflammation may partly account for the association of remnant-C with NAFLD [36–38].