NOTCH1 and neoplasm: ( 37 ) Single and combination siRNA treatments of STAT3 (involved in tumor growth and drug resistance ( 37 ) ), Notch1 (related to tumor formation and aggressiveness ( 38 ) ), and β-catenin (associated with cancer cells proliferation rate and resistance ( 39 ) ) in the MDA-MB-231 TNBC cell line demonstrated that enhanced chemosensitization to doxorubicin and decreased cell viability.