To evaluate the effect of the polytherapy on the body weights, serum insulin, homeostatic model assessment insulin resistance (HOMA-IR), oxidative stress index (malondialdehyde–MDA), antioxidant status (superoxide dismutase–SOD, glutathione peroxidase–GPx, reduced glutathione–GSH, glutathione-S-transferase–GST), oxidative stress index (MDA) and inflammatory markers (nuclear factor kappa B–NFkB, TNF-α, inducible nitric oxide synthase–iNOS, VEGF) in the sera of the diabetic rats;. This evidence concerns the gene INS and Insulin resistance.