In the RS cortex of female APP/PS1 AD mice, 25 candidates exhibited signature character, i.e., Gusb, Slc14a1, Mir142hg, Cyth4, Gpr34, Plek, Ccl9, Aif1, Psmb9, Lair1, Hk3, Csf2rb, Tlr12, Adora3, Apbb1ip, Pycard, Vav1, Oas1a, Ifi27l2a, Hexb, Ncf4, Fcrls, Irf5, Havcr2, Mlxipl. Here, GPR34 is linked to Alzheimer disease.