As APP/PS1 mice exhibit similar phenotypical features as 5XFAD animals, we analyzed the same set of critical 5XFAD related genes via qPCR in the APP/PS1 model, i.e., Cacna1c, Cacna1d, Plcd4, Casp8, Chrm1, Chrm3, and Chrm5, to elaborate whether there are common, relevant DEGs in both AD mouse models (first qPCR approach). This evidence concerns the gene CACNA1D and Alzheimer disease.