In the hippocampus of female APP/PS1 AD mice, these signature genes included 13 candidates (Asic4, Pcsk1, Etnppl, Myh7b, Spag5, Gpr1, Myh8, Ccdc184, Pdzph1, Trim66, BC030499, Rims3, Prr16), only two candidates (LOC105247294, Ptpn6) in the RS cortex of female APP/PS1 AD mice, six gene candidates in the hippocampus of male APP/PS1 AD mice (4933407I18Rik, Hlcs, Hdac9, Pla2g4e, Wnt9a. This evidence concerns the gene CMKLR2 and Alzheimer disease.