We previously demonstrated that neurodegenerative alterations in the motor cortex and septohippocampal system of APP/PS1 mice (but also in other AD lines such as 5XFAD) can result in complex central dysrhythmia [32], particularly in the theta (4–8 Hz) and two distinct gamma frequency ranges (30–50 Hz and 50–70 Hz) [13, 14]. The gene discussed is APP; the disease is Alzheimer disease.