APP and Alzheimer disease: In the RS cortex of female APP/PS1 AD mice, 25 candidates exhibited signature character, i.e., Gusb, Slc14a1, Mir142hg, Cyth4, Gpr34, Plek, Ccl9, Aif1, Psmb9, Lair1, Hk3, Csf2rb, Tlr12, Adora3, Apbb1ip, Pycard, Vav1, Oas1a, Ifi27l2a, Hexb, Ncf4, Fcrls, Irf5, Havcr2, Mlxipl.