APP and Alzheimer disease: In total, 14 candidates were exclusively downregulated in the female hippocampus of APP/PS1 mice, two were exclusively downregulated in the cortex of female APP/PS1 mice, but only one candidate was co-downregulated in both the cortex and hippocampus of female APP/PS1 AD vs. WT mice, i.e., Pisd-ps3 (S9B Table in S1 File).