In the RS cortex of female APP/PS1 AD mice, 25 candidates exhibited signature character, i.e., Gusb, Slc14a1, Mir142hg, Cyth4, Gpr34, Plek, Ccl9, Aif1, Psmb9, Lair1, Hk3, Csf2rb, Tlr12, Adora3, Apbb1ip, Pycard, Vav1, Oas1a, Ifi27l2a, Hexb, Ncf4, Fcrls, Irf5, Havcr2, Mlxipl. The gene discussed is HEXB; the disease is Alzheimer disease.