In the RS cortex of female APP/PS1 AD mice, 25 candidates exhibited signature character, i.e., Gusb, Slc14a1, Mir142hg, Cyth4, Gpr34, Plek, Ccl9, Aif1, Psmb9, Lair1, Hk3, Csf2rb, Tlr12, Adora3, Apbb1ip, Pycard, Vav1, Oas1a, Ifi27l2a, Hexb, Ncf4, Fcrls, Irf5, Havcr2, Mlxipl. The gene discussed is APBB1IP; the disease is Alzheimer disease.