In the hippocampus of male APP/PS1 AD mice, exclusive upregulation was observed in 18 gene candidates, i.e., Sgk1, Ncf1, Adamtsl4, Hck, St8sia6, Gm20743, Irf9, Pfkfb3, B2m, Arrdc2, Cebpa, Synpo2, Cep126, Rhoh, Hist1h2be, Clec5a, Cd86, Ptpn18. This evidence concerns the gene PFKFB3 and Alzheimer disease.