Enriched upregulated gene candidates (FC > 1.5, indicated via gene symbols) are depicted for the top 10 related categories/cluster terms derived from GO analysis (see also Fig 2) for (A) the RS cortex of female APP/PS1 AD mice, (B) the hippocampus of female APP/PS1 AD mice, (C) the RS cortex of male APP/PS1 AD mice, and (D) the hippocampus of male APP/PS1 AD mice. The gene discussed is APP; the disease is Alzheimer disease.