In our study design, 17 gene candidates turned out to be exclusively upregulated in the hippocampus of female APP/PS1 AD mice, i.e., Prss23, Slc38a5, Ifitm3, Icam1, Dclk1, Rfx3, Tubb6, Slfn5, Flnc, Apobec1, Lsp1, Myo1g, Vim, 5830408C22Rik, Ptgr1, Pla2g4a, Rab32. The gene discussed is SLFN5; the disease is Alzheimer disease.