In the hippocampus of male APP/PS1 AD mice, exclusive upregulation was observed in 18 gene candidates, i.e., Sgk1, Ncf1, Adamtsl4, Hck, St8sia6, Gm20743, Irf9, Pfkfb3, B2m, Arrdc2, Cebpa, Synpo2, Cep126, Rhoh, Hist1h2be, Clec5a, Cd86, Ptpn18. The gene discussed is ADAMTSL4; the disease is Alzheimer disease.