CASP8 and Alzheimer disease: As APP/PS1 mice exhibit similar phenotypical features as 5XFAD animals, we analyzed the same set of critical 5XFAD related genes via qPCR in the APP/PS1 model, i.e., Cacna1c, Cacna1d, Plcd4, Casp8, Chrm1, Chrm3, and Chrm5, to elaborate whether there are common, relevant DEGs in both AD mouse models (first qPCR approach).