Enriched downregulated gene candidates (FC < -1.2, indicated via gene symbols) are depicted for the related categories/cluster terms derived from GO analysis (see also Fig 3) for (A) the RS cortex of female APP/PS1 AD mice, (B) the hippocampus of female APP/PS1 AD mice, (C) the RS cortex of male APP/PS1 AD mice, and (D) the hippocampus of male APP/PS1 AD mice. The gene discussed is APP; the disease is Alzheimer disease.