PPM1H and Parkinson disease: To demonstrate the utility of the CURTAIN and CURTAIN-PTM tools, we employed an inducible protein degradation strategy termed the BromoTag (36), to rapidly deplete the endogenous levels of a protein phosphatase termed PPM1H, that was previously shown to dephosphorylate the Rab10 substrate that is phosphorylated by the LRRK2 protein kinase implicated in Parkinson’s disease (23).