To demonstrate the utility of the CURTAIN and CURTAIN-PTM tools, we employed an inducible protein degradation strategy termed the BromoTag (36), to rapidly deplete the endogenous levels of a protein phosphatase termed PPM1H, that was previously shown to dephosphorylate the Rab10 substrate that is phosphorylated by the LRRK2 protein kinase implicated in Parkinson’s disease (23). Here, LRRK2 is linked to Parkinson disease.