In addition, the expression level of PBX3 in glioma patients with tumor was higher than that in patients without tumor and the expression level of PBX3 in glioma patients ((Fig 2I) and karnofsky performance score ≦60 was significantly higher than that in patients karnofsky performance score >60 according to TCGA(Fig 2J). This evidence concerns the gene PBX3 and central nervous system cancer.