APC and cancer: Comparison of the APC-mutant cancer organoids shows that APC is more frequently mutated in CSC-406 (nonsense Q1045*, allele frequency 0.5 / Fs insertion P1594Afs*38, allele frequency 0.45) compared to POP-092 (nonsense G1499*, allele frequency 0.65) consistent with higher WNT pathway activity in CSC-406 that correlates with higher β‐catenin protein compared to the POP-092 line.