The role of β‐catenin in mediating centrosome loss-induced cancer organoid death was confirmed in both APC-mutant lines (CSC-406 and POP-092) since the inhibition of β-catenin/TCF mediated transcription using ICG-001 partially prevented centrinone-induced death of both lines, although the effect on organoid growth rate was insignificant compared to XAV939, most probably due to ICG-001 cell toxicity effect [20]. The gene discussed is APC; the disease is cancer.