TBC1D4 and obesity due to melanocortin 4 receptor deficiency: Insulin-stimulated TBC1D4 (Thr642) phosphorylation exhibited a trend to be repressed with obesity (P = 0.10); this difference became more evident after resveratrol treatment in pThr642 and pSer704 (P < 0.05) (Fig. 3, A–C).