Several ADAMTSLs are emerging as important in CVD, i.e., ADAMTSL1 locus in cardiac fibrosis, ADAMTSL6 genetic variants in aorthopathies, ADAMTSL2 in GD and heart failure, ADAMTSL4 in coronary artery dissection and ADAMTSL3 in mouse heart failure, where they represent opportunities for therapeutic intervention. This evidence concerns the gene ADAMTSL4 and heart failure.