Strong evidence for a role in human cardiac fibrosis comes from the recent UK Biobank GWAS where ADAMTSL1 was discovered among eleven genetic loci linked to cardiac fibrosis [4], including in patients with diabetes mellitus, renal disease, aortic stenosis, cardiomyopathy, heart failure, atrial fibrillation, and rheumatoid arthritis. The gene discussed is ADAMTSL1; the disease is heart failure.