TGFB1 and heart failure: Lack of ADAMTSL2 in the ECM is the underlying cause for GD, with a cardiac phenotype and molecular pathology related to increased TGFβ activity [10], as well as the cause for tissue fibrosis in beagle dogs [18], while significantly associated with human fibrosis of the liver [6] ADAMTSL2 may be an important player in development of cardiac fibrosis, as levels increase considerably in the myocardium and circulation of patients and mice during heart failure development [5, 9, 40].