Mutations in ADAMTS10 and ADAMTS17 phenocopy mutations in ADAMTSL4 (ectopia lentis) [48] and ADAMTSL2 (acromelic dysplasias) [16], suggesting common functional pathways, and ADAMTSL3 also binds directly to ADAMTS10 [19]. The gene discussed is ADAMTSL4; the disease is isolated ectopia lentis.