Mutations in genes of the canonical signaling pathway, i.e., TGFB1/2/3, TGFBR1/2, and SMAD2/3/4, result in CVDs such aortic aneurysms and aortic dissections, congenital heart defects, cardiac arrythmias, and heart failure [14]. Here, TGFB1 is linked to heart failure.