Western blotting revealed that circZNF800 silencing decreased AKT phosphorylation (p-Akt) in GBM cells (Fig. 2P and Supplementary Fig. 2O), whereas overexpressing circZNF800 increased AKT phosphorylation (Fig. 2Q and Supplementary Fig. 2P). This evidence concerns the gene AKT1 and glioblastoma.