19 of the 55 angiogenesis-related proteins analyzed such as TIMP-1/4, MMP-8/9, PDGF-AA/AB-BB, CXCL4/16, IGFBP-1/2, Tissue Factor/Factor III, Endoglin or Angiogenin were significantly downregulated at 3-months post-COVID-19 patients compared to healthy controls and this decrease remained significantly downregulated at 6 and 12-months post-infection (Fig. 3A, B). This evidence concerns the gene MMP8 and infection.