ANGPT2 and COVID-19: Additionally, 13 of 55 angiogenic proteins including TIMP-1, uPA, VEGF, MMP-8/9, CXCL4/16, Endoglin, Angiogenin or Angiopoietin-2 were uniquely downregulated in 3-months post-COVID-19 patients without PE compared to those who suffered a PE (Fig. 4A, B).