AKT1 and hepatocellular carcinoma: In human hepatocellular carcinoma cells SMCC-7721, PPI was able to inhibit cell proliferation by regulating the PI3K/mTOR signaling pathway [16]; moreover, Pang et al. found that PPII was able to inhibit the proliferation of hepatocellular carcinoma SMCC-7721 cells and exert antitumor effects by inhibiting the AKT/NF-κB signaling pathway [15].