BCL2 and hepatocellular carcinoma: Li et al. found that PP-26 can inhibit Akt/ GSK-3β/Foxo3 signaling pathway expression, while downregulating caspase-3, and-9, PARP, Bcl-2, and MCL-1, and upregulating BAX expression to induce apoptosis in hepatocellular carcinoma HepG2 cells [43].