Kaempferol treatment significantly downregulated the expression levels of p-EGFR, p-AKT, p-ERK1/2, and Bcl-2, while kaempferol in combination with ERL significantly inhibited pancreatic cancer cell proliferation and induced apoptosis through upregulation expression of caspase-9, PARP, and BAX. The gene discussed is AKT1; the disease is pancreatic neoplasm.