Kaempferol treatment significantly downregulated the expression levels of p-EGFR, p-AKT, p-ERK1/2, and Bcl-2, while kaempferol in combination with ERL significantly inhibited pancreatic cancer cell proliferation and induced apoptosis through upregulation expression of caspase-9, PARP, and BAX. This evidence concerns the gene AKT1 and familial pancreatic carcinoma.