In patients with pancreatic cancer, high TGM2 expression was positively associated with a poor prognosis.Kaempferol induces ROS-dependent apoptosis by downregulating TGM2 and the Akt/mTOR signaling pathway in PANC-1 and Mia PaCa-2 pancreatic cancer cells. This evidence concerns the gene TGM2 and familial pancreatic carcinoma.