At the initial response (2 hours), genes that have been associated with inflammation, bone loss, and susceptibility to periodontitis, such as FOSB and PLCG2, suppressors of cytokine signaling, and PTGS2, involved in prostaglandin biosynthesis (58, –, 60), were upregulated in cells infected with the wild type. This evidence concerns the gene PTGS2 and periodontitis.