G6PD and G6PD deficiency: In addition, no mention was made that, in one of the constituent studies (which examined the dose–response for haemoglobin decline in participants with 40–60% G6PD enzyme activity) (Rueangweerayut et al., 2017), dose escalation of tafenoquine from 300 mg to 600 mg was not attempted due to safety concerns about potential haemolysis in patients with G6PD deficiency.