For T cells, the onset of ischemic stroke was associated with an increase in CC‐chemokine receptor 7 (CCR7) on immature CD8+ T cells (IVW: β = 0.17, 95% CI 0.00–0.33; p = 0.047), CD25 on CD45RA– CD4 non‐regulatory T cells (IVW: β = 0.17, 95% CI 0.02–0.31; p = 0.025), and side scatter (SSC)‐A on HLA DR+ CD8+ T cells (IVW: β = 0.18, 95% CI 0.03–0.33; p = 0.020). Here, CD8A is linked to ischemic stroke.