In T cells, CD8 on CD28+ CD45RA– CD8+ T cells (IVW: OR 1.09, 95% CI 1.02–1.17; p = 0.016) and herpes virus entry mediator (HVEM) on immature CD8+ T cells (IVW: OR 1.04, 95% CI 1.01–1.08; p = 0.009) were associated with increased stroke risk. This evidence concerns the gene CD8A and stroke disorder.