ZSWIM4 and acute myeloid leukemia: Additionally, zswim4 mutations frequently occur in patients with acute myelogenous leukemia (Walter et al., 2012), while zswim6 mutations in mammals associate with acromelic frontonasal dysostosis (a rare disease characterized by craniofacial, brain and limb malformations), and schizophrenia (Smith et al., 2014; Tischfield et al., 2017).