PRNP and early-onset autosomal dominant Alzheimer disease: Based on this study, the functions carried out by the PrPC protein have been determined to be homoeostasis (AccessisdeniedAccessisdenied and Zn2+ binding), cellular signalling, ion channel regulation, modulating neuronal excitability via NMDA receptor, cell adhesion (neurite outgrowth), maintaining peripheral nerve myelin, neuronal survival and differentiation, protection from reactive oxygen, and as a receptor for amyloid-β oligomers in Alzheimer disease [6].