GPX4 and non-small cell lung carcinoma: In several NSCLC cell lines, researches demonstrated that irradiation also triggers rising expression level of SLC7A11 and GPX4, as an adaptive response to resist ferroptosis, while upon introducing erastin, the state of radioresistance of NSCLC is counteracted, partially achieved due to GPX-4 mediated pathway inhibition 139, 142, 145.