Consistent with the predictive results in the metabolic distress, patients with chronic colitis exhibiting high expression of pivotal signaling mediators such as EGR1, SREBP2, and HuR showed elevated levels of LDLR expression (Figure 8F), indicating a positive involvement of these signaling molecules in LDLR expression in IBD (Figure S7A-S7C). This evidence concerns the gene EGR1 and inflammatory bowel disease.