We also conducted co-culture experiments in B16-F10 murine melanoma cells, MC38 murine colon carcinoma cells, SCC7 murine squamous cell carcinoma cells, and Hepa1-6 murine hepatoma cells, respectively, which showed an consistent upregulation of CD73 in BMDMs co-culturing with senescent tumor cells (Figure S2B). The gene discussed is NT5E; the disease is hepatocellular carcinoma.